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Cyclo(Arg-Gly-Asp-D-Phe-Val)TFA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cyclo(Arg-Gly-Asp-D-Phe-Val)TFA图片
CAS NO:199807-33-5
规格:98%
分子量:688.65
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Cyclo(Arg-Gly-Asp-D-Phe-Val)(TFA)是整合蛋白αvβ3的抑制剂,具有抗肿瘤活性。
CAS:199807-33-5
分子式:C28H39F3N8O9
分子量:688.65
纯度:98%
存储:Store at -20°C

Background:

Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin αvβ3, with antitumor activity.


Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin αvβ3. Cyclo(Arg-Gly-Asp-D-Phe-Val) [c(RGDfV); 35 nM] induces disruption of leukemia cell migration and adhesion to leukemia osteoblasts in the 3D and 2D culture systems, affects the leukemia cell cycle and induces apoptosis in leukemia cells[1].



[1]. Shen ZH, et al. Targeting of the leukemia microenvironment by c(RGDfV) overcomes the resistance to chemotherapy in acute myeloid leukemia in biomimetic polystyrene scaffolds. Oncol Lett. 2016 Nov;12(5):3278-3284.