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G3-C12
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:848301-94-0
规格:98%
分子量:1758.98
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
G3-C12是galectin-3结合肽,Kd值为88nM,具有抗肿瘤活性。
CAS:848301-94-0
分子式:C74H115N23O23S2
分子量:1758.98
纯度:98%
存储:Store at -20°C

Background:

G3-C12 is a galectin-3 binding peptide, with Kd of 88 nM, and shows anticancer activity.


G3-C12 is a galectin-3 binding peptide, with high affinity (Kd) of 88 nM, but shows no affinity for other galectin family members or to other lectins. G3-C12 bearing opolymers N-(2-hydroxypropyl)methacrylamide (HPMA) potently and selectively targets colorectal cancer (CRC) tumour cells over-expressing galectin-3 and displays superior targetability to galectin-3 compared to the galactose bearing copolymer[1].



[1]. Kopansky E, et al. Peptide-directed HPMA copolymer-doxorubicin conjugates as targeted therapeutics for colorectal cancer. J Drug Target. 2011 Dec;19(10):933-43.