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CI 972(anhydrous)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CI 972(anhydrous)图片
CAS NO:115787-68-3
规格:98%
分子量:297.76
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
CI 972 anhydrous 是一会有效的,具有口服活性的,竞争性的嘌呤核苷磷酸化酶 (PNP) (Ki=0.83 μM),正在开发作为T细胞选择性免疫抑制剂。
CAS:115787-68-3
分子式:C11H12ClN5OS
分子量:297.76
纯度:98%
存储:Store at -20°C

Background:

CI 972 anhydrous is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent[1][2]. Ki: 0.83 μM (PNP)[1]



CI 972 anhydrous (5-150 mg/kg; p.o.) produces dose-dependent elevation of plasma inosine one hour after administration to rats[1].


[1]. Gilbertsen RB, et al. Biochemical and pharmacological properties of CI-972, a novel 9-deazaguanine analog purine nucleoside phosphorylase (PNP) inhibitor. Adv Exp Med Biol. 1991;309A:41-4. [2]. Gilbertsen RB,et al. Selective in vitro inhibition of human MOLT-4 T lymphoblasts by the novel purine nucleoside phosphorylase inhibitor, CI-972. Biochem Biophys Res Commun. 1991 Aug 15;178(3):1351-8.