Cyclosporin A-Derivative 1 是环孢菌素 A 衍生的结晶中间体，来自专利 WO 2013167703 A1。Cyclosporin A 是一种免疫抑制剂，能够与亲环蛋白结合并抑制钙调磷酸酶。
CAS：1487360-85-9
分子式：C65H118BF4N11O14
分子量：1364.5
纯度：98%
存储：Store at -20°C

Background:

Cyclosporin A-Derivative 1 is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.

Cyclosporin A-Derivative 1 is a non-immunosuppressive Cyclosporine A derivative. The cyclosporin is acylated on the butenyl-methyl-threonine side chain and then subjected to a ring-opening reaction (the ring opens between the sarcosine and the N-methyl-leucine residues). Cyclosporin A-Derivative 1 is a linear peptide intermediate[1].

[1]. Fabrice Gallou, et al. Process for the manufacture of cyclic undecapeptides. WO 2013167703 A1.