您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Indirubin Derivative E804
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Indirubin Derivative E804
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Indirubin Derivative E804图片
CAS NO:854171-35-0
规格:98%
分子量:365.38
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
Indirubin Derivative E804, 是类胰岛素生长因子1型受体 (IGF1R) 的有效抑制剂,其 IC50 值为 0.65 μM。
CAS:854171-35-0
分子式:C20H19N3O4
分子量:365.38
纯度:98%
存储:Store at -20°C

Background:

E 804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM for IGF1R. IC50: 0.65 μM (IGF1R)[1].


Indirubin Derivative E804 is a water-soluble indirubin derivative as potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM. Indirubin Derivative E804 also inhibits CDK2/CycE with an EC50 of 0.23 μM[1].



[1]. Cheng X, et al. Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule. J Med Chem. 2017 Jun 22;60(12):4949-4962.