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Carmofur
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Carmofur图片
CAS NO:61422-45-5
规格:98%
分子量:257.26
包装与价格:
包装价格(元)
5mg电议
100mg电议

产品介绍
Cytostatic derivative of fluorouracilm,antineoplatic agent
CAS:61422-45-5
分子式:C11H16FN3O3
分子量:257.26
纯度:98%
存储:Store at -20°C

Background:

Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent. Target: Nucleoside antimetabolite/analogCarmofur, which is used in the clinic to treat colorectal cancers, is a potent AC inhibitor and that this property is essential to its anti-proliferative effects. Carmofur inhibited AC activity with a median effective concentration (IC50) of 29 ± 5 nM (mean ± standard error of the mean, s.e.m.; n = 4), whereas 5-FU had no such effect (IC50>1 mM). systemic administration of carmofur (10 or 30 mg-kg-1, intraperitoneal, i.p.) to mice produced a dose-dependent inhibition of AC activity in various tissues, including lungs and brain cortex.


参考文献:
[1]. Realini, N., et al., Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity. Sci Rep, 2013. 3: p. 1035.