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Sal 003
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sal 003图片
CAS NO:1164470-53-4
规格:98%
分子量:463.21
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
Cellular phosphatase complex inhibitor
CAS:1164470-53-4
分子式:C18H15Cl4N3OS
分子量:463.21
纯度:98%
存储:Store at -20°C

Background:

Eukaryotic initiation factor 2 α-subunit (eIF2α) plays a critical role in the regulation of protein synthesis. Moreover, it also plays an important role in synaptic plasticity and long-term memory consolidation. Sal003 is a selective inhibitor of eIF2α dephosphorylation.


In vitro: Sal003 specifically prevents dephosphorylation of eIF2α by blocking eIF2α phosphatases. In Sal003-treated cells polysomes dissociated and consistent with this β-actin mRNA shifted to lighter fractions, reflecting the inhibition of general translation [1].


In vivo: Intra-basolateral amygdala (BLA) infusions of Sal003 immediately after memory retrieval disrupted the reconsolidation of morphine- or cocaine-induced CPP, leading to a long-lasting suppression of drug-paired stimulus-induced craving. Moreover, inhibition of eIF2α dephosphorylation in the BLA immediately after light/tone stimulus retrieval decreased subsequent cue-induced heroin-seeking behavior in the self-administration procedure. These results demonstrate that eIF2α dephosphorylation in the BLA mediates the memory reconsolidation of drug-paired stimuli [1].


Clinical trials: Currenlty no clinical data are available.


Reference:
[1] Jian M, Luo YX, Xue YX, Han Y, Shi HS, Liu JF, Yan W, Wu P, Meng SQ, Deng JH, Shen HW, Shi J, Lu L.   eIF2α dephosphorylation in basolateral amygdala mediates reconsolidation of drug memory. J Neurosci. 2014;34(30):10010-21.