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DL-threo-PPMP(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DL-threo-PPMP(hydrochloride)图片
CAS NO:139974-41-7
规格:98%
分子量:511.2
包装与价格:
包装价格(元)
5mg电议
25mg电议
50mg电议
100mg电议

产品介绍
inhibitor of glucosylceramide synthase
CAS:139974-41-7
分子式:C29H50N2O3 ? HCl
分子量:511.2
纯度:98%
存储:Store at -20°C

Background:

DL-threo-PPMP (hydrochloride) is an inhibitor of glucosylceramide synthase [1].


Glucosylceramide synthase (GCS) is a pervasive enzyme inherent to intracellular ceramide metabolism. The enzyme has been involved in catalyzing the transfer of glucose to ceramide, which is the principle committed step in glycolipid biosynthesis. GCS has been involved in the cytotoxic response of cancer cells to chemotherapy. Glucosylceramide synthase-based sphingolipids have been identified as important mediators of a variety of cellular functions, including proliferation, differentiation, development, and cell-cell recognition [2].


DL-threo-PPMP was a ceramide analog. DL-threo-PPMP inhibited the activity of glucosylceramide synthase with an IC50 value between 2 and 20 μM. It has been used to study the role of glucosylceramide synthase in cell growth, apoptosis, and autophagy [1].


参考文献:
[1] Lee L, Abe A, Shayman J A.  Improved inhibitors of glucosylceramide synthase[J]. Journal of Biological Chemistry, 1999, 274(21): 14662-14669.
[2] Bleicher R J, Cabot M C.  Glucosylceramide synthase and apoptosis[J]. Biochimica et biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2002, 1585(2): 172-178.