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Carbazochrome sodium sulfonate(AC-17)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Carbazochrome sodium sulfonate(AC-17)图片
CAS NO:51460-26-5
包装:50mg
规格:98%
市场价:579元
分子量:322.27

产品介绍
antihemorrhagic agent
CAS:51460-26-5
分子式:C10H11N4NaO5S
分子量:322.27
纯度:98%
存储:Store at -20°C

Background:

Carbazochrome (sodium sulfonate) (AC-17) is an antihemorrhagic agent.Target: OthersCarbazochrome is an antihemorrhagic agent that will cease blood flow by causing the aggregation and adhesion of platelets in the blood to form a platelet plug, ceasing blood flow from an open wound. It is hoped that this drug can be used in the future for preventing excessive blood flow during surgical operations and the treatment of hemorrhoids. Carbazochrome interacts with α-adrenoreceptors on surface of platelets, which are coupled to Gq protein and initiate PLC IP3/DAG pathway to increase intracellular free calcium concentration with these subsequent actions. Activates PLA2 and induce arachidonic acid pathway to synthese endoperoxides (TxA2, thromboxane A2). Calcium binds to calmodulin which then binds and activates myosin light-chain kinase, that will enable the myosin crossbridge to bind to the actin filament and allow contraction to begin. This will change platelet's shape and induce release of serotonin, ADP, vWF (Von Willebrand factor), PAF (Platelet-activating factor) to promote further aggregation and adhesion. From Wikipedia.


参考文献:
[1]. http://en.wikipedia.org/wiki/Carbazochrome