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14,15-dehydro Leukotriene B4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
14,15-dehydro Leukotriene B4图片
CAS NO:114616-11-4
规格:98%
分子量:334.5
包装与价格:
包装价格(元)
25ug电议
50ug电议
100ug电议

产品介绍
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway.
CAS:114616-11-4
分子式:C20H30O4
分子量:334.5
纯度:98%
存储:Store at -20°C

Background:

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. At least two LTB4 receptors, termed BLT1 and BLT2, have been identified. 14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value of 27 nM, compared to BLT2, which has a Ki value of 473 nM. 14,15-dehydro LTB4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 µM.