Parishin C is a phenolic glycoside and a major component of G.
CAS：174972-80-6
分子式：C32H40O19
分子量：728.7
纯度：98%
存储：Store at -20°C

Background:

Parishin C is a phenolic glycoside and a major component of G. elata. It prevents inhibition of NMDA receptor (NMDAR) currents induced by amyloid-β (1-42) (Aβ42) in rat hippocampal neurons when used at a concentration of 2 μM. In vivo, parishin C (20 mg/kg) prevents Aβ42-induced inhibition of long-term potentiation (LTP) in rats. Parishin is an agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 1.54 nM; EC50 = 34 nM for [35S]GTPγS binding) that reverses phencyclidine-induced increases in immobility time in the forced swim test, phencyclidine-induced decreases in interaction time in the social interaction test, and phencyclidine-induced impairments in visual recognition of a novel object in mice.