Background:

KW-6055 is a benzylpyridine derivative and has anti-amnesic activity.

KW-6055 is a benzylpyridine derivative and has anti-amnesic activity. KW-6055 (40, 160 mg/kg, p.o.) increases the extracellular level of ACh in normal rats (257±23, 202±24%). In basal forebrain-lesioned rats, KW-6055 (40 mg/kg, p.o.) significantly increases the extracellular level of ACh (251±22%) for more than 2 hr, which is longer than in normal rats[1].

[1]. Kurokawa M, et al. Effects of KW-6055, a novel benzylpyridine derivative, on central cholinergic systems. Nihon Yakurigaku Zasshi. 1992 Jun;99(6):435-43.