Background:

3-CPs is a serotype capsular polysaccharide which can interfere with antibody-mediated bacterial killing.

3-CPs displays protective effect against UVB damage in all concentrations tested[1]. About 50% inhibition of bacterial killing is observed when 12 ng of purified type 3 CPS is added to the OPKA. The addition of 30 μL of mouse serum post-i.p. infection with WU2 (containing 0.4 to 0.7 μg/mL released type 3 CPS) shows 26% to 52% inhibition of bacterial killing, comparable to what is observed when an equivalent amount of purified CPS is added[2].

[1]. Silva EB, et al. Modulation of the UVB-induced lethality by furocoumarins in Staphylococcus aureus. J Photochem Photobiol B. 2014 Jan 5;130:260-3. doi: 10.1016/j.jphotobiol.2013.11.012. [2]. Choi EH, et al. Capsular Polysaccharide (CPS) Release by Serotype 3 Pneumococcal Strains Reduces the Protective Effect of Anti-Type 3 CPS Antibodies.