CAS NO: | 139755-83-2 |
规格: | 98% |
分子量: | 474.58 |
包装 | 价格(元) |
25mg | 电议 |
50mg | 电议 |
500mg | 电议 |
Background:
Sildenafil is a selective inhibitor of phosphodiesterase-5 (PDE5) [1].
Phosphodiesterases (PDEs) are enzymes that hydrolyzing cyclic nucleotides cAMP and cGMP to their inactive 5’-monofosfatos forms. The PDE5 enzyme is responsible for the hydrolysis of the cGMP, which restores GMP levels [1].
In human umbilical vein endothelial cells (HUVECs), Sildenafil (1 mM/5 h) significantly enhanced NO production, which is