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Sildenafil
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sildenafil图片
CAS NO:139755-83-2
规格:98%
分子量:474.58
包装与价格:
包装价格(元)
25mg电议
50mg电议
500mg电议

产品介绍
PDE5 inhibitor, selective
CAS:139755-83-2
分子式:C22H30N6O4S
分子量:474.58
纯度:98%
存储:Store at -20°C

Background:

Sildenafil is a selective inhibitor of phosphodiesterase-5 (PDE5) [1].
Phosphodiesterases (PDEs) are enzymes that hydrolyzing cyclic nucleotides cAMP and cGMP to their inactive 5’-monofosfatos forms. The PDE5 enzyme is responsible for the hydrolysis of the cGMP, which restores GMP levels [1].
In human umbilical vein endothelial cells (HUVECs), Sildenafil (1 mM/5 h) significantly enhanced NO production, which is