Background:

Calcitriol is a form of Vitamin D, is converted to metabolites more potent and rapidly acting than other forms of Vitamin D [1].

Calcitriol has played an important role in mineral and skeletal homeostasis by regulating the differentiation, growth and the function of the cell immune system. In vitro studies, Calcitriol has been reported to dose-dependently inhibit the production of tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) in human peripheral blood cells (PBMC) stimulated by LPS. Furthermore, Calcitriol has been revealed to significantly reduced the basal intradialytic increases of TNF-αand IL-1βin vivo studies. Apart from these, Calcitriol has also been reported to modulate the cytokine production indirectly through the effect on calcium and PTH metabolism [2].

参考文献:
[1] Holick MF, Schnoes HK, DeLuca HF. Identification of 1,25-dihydroxycholecalciferol, a form of vitamin D3 metabolically active in the intestine. Proc Natl Acad Sci U S A. 1971 Apr;68(4):803-4.
[2] Panichi V1, De Pietro S, Andreini B, Bianchi AM, Migliori M, Taccola D, Giovannini L, Tetta C, Palla R. Calcitriol modulates in vivo and in vitro cytokine production: a role for intracellular calcium. Kidney Int. 1998 Nov;54(5):1463-9.