Background:

Destruxin A is a cyclic hexadepsipeptide mycotoxin first isolated fromO. destructorand commonly found in entomopathogenic fungi.¹It has insecticidal activity by affecting diverse pathways, including those related to immune response, calcium signaling, and development.^2,3

参考文献:

1. Pedras, M., Zaharia, L.I., and Ward, D.E. The destruxins: Synthesis, biosynthesis, biotransformation, and biological activity Phytochemistry 59(6), 579-596 (2002).
2. Han, P., Jin, F., Dong, X., et al. Transcript and protein profiling analysis of the Destruxin A-induced response in larvae of Plutella xylostella PLoS One 8(4), (2013).
3. Pal, S., St.Leger, R.J., and Wu, L.P. Fungal peptide Destruxin A plays a specific role in suppressing the innate immune response in Drosophila melanogaster J.Biol.Chem. 282(12), 8969-8977 (2007).