UK-157147是一种UDP-葡萄糖醛酸转移酶(UGT1A1)的底物，Km值为105μM。
CAS：162704-20-3
分子式：C23H24N2O7S
分子量：472.51
纯度：98%
存储：Store at -20°C

Background:

UK-157147 is a substrate for UDP-glucuronosyltransferases (UGT1A1) with a Km value of 105 μM.

Glucuronidation is an important pathway for human drug metabolism. Four cloned and expressed human UDP-glucuronosyltransferases (UGT1A1, UGT1A6, UGT1A9, and UGT2B15) are used to screen a series of three potential drug substrates differing only in position of the phenol moiety. The para phenol UK-157147 (UK-157,147) is found to be a substrate for UGT1A1 with a Km value of 105 μM[1].

[1]. Ethell BT, et al. Use of cloned and expressed human UDP-glucuronosyltransferases for the assessment of human drug conjugation and identification of potential drug interactions. Drug Metab Dispos. 2001 Jan;29(1):48-53.