BLXA 4 is a novel lipoxin analog that is able to promote regeneration of hard and soft tissues irreversibly lost to
periodontitis in the Hanford miniature pig.bLXA₄ dramatically reduced inflammatory cell
infiltrate into chronic periodontal disease sites treated surgically
and dramatically increased new bone formation and regeneration of the
periodontal organ. These findings indicate that bLXA4 is a mimetic
of endogenous resolving mechanisms with potent bioactions that offers a
new therapeutic tissue-engineering approach for the treatment of chronic
osteolytic inflammatory diseases. It can be potentially used for the treatment of gingival diseases.