| CAS NO: | 6036-75-5 |
| 规格: | 98% |
| 分子量: | 299.5 |
| 包装 | 价格(元) |
| 500ug | 电议 |
| 1mg | 电议 |
Background:
L-erythro Sphingosine is a synthetic stereoisomer of sphingosine (d18:1) . It inhibits protein kinase C (PKC) in vitro (IC50 = 3.3 mol%) and superoxide generation induced by phorbol 12-myristate 13-acetate in neutrophils as well as reduces growth of CHO cells (IC50s = 1.3 and 2 μM, respectively). L-erythro Sphingosine also inhibits dephosphorylation of the tumor suppressor retinoblastoma gene product (pRb; EC50 = 5 μM) and growth of MOLT-4 acute lymphoblastic leukemia cells (IC50 = 3.7 μM).
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