Background:

Timobesone is a topical corticosteroid but never marketed.

The increase in the solubility of Timobesone acetate in the micellar solutions is dependent on the type and concentration of surfactant. The solubilizing capacity of the surfactant micelles and the distribution coefficient of Timobesone acetate in aqueous micellar solutions are found to increase with increasing length of the hydrophobic fatty acid group[1].

[1]. Ong JT, et al. Micellar solubilization of timobesone acetate in aqueous and aqueous propylene glycol solutions of nonionic surfactants. Pharm Res. 1988 Nov;5(11):704-8.