DS28120313 是一种口服型铁调素 (hepcidin) 生成抑制剂, IC50值为 0.093 μM。
CAS：2146177-09-3
分子式：C16H17N5O2
分子量：311.34
纯度：98%
存储：Store at -20°C

Background:

DS28120313 (compound 32) is an orally hepcidin production inhibitor with an IC50 of 0.093 μM[1]. IC50: 0.093 μM (hepcidin production)[1]

DS28120313 (deliver orally; 30 mg/kg; 30 min before IL-6 administration) inhibits hepcidin production and reduces the blood hepcidin level in IL-6 induced acute inflammatory C57BL/6 mouse model[1].

[1]. Fukuda T, et al. Discovery of DS28120313 as a potent orally active hepcidin production inhibitor: Design and optimization of novel 4,6-disubstituted indazole derivatives. Bioorg Med Chem Lett. 2017 Dec 1;27(23):5252-5257.