positive allosteric modulator of the AMPA and kainate receptors
CAS：364-98-7
分子式：C8H7ClN2O2S
分子量：230.67
纯度：98%
存储：Store at -20°C

Background:

3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-dioxide (Sch-6783) is an ATP-sensitive potassium channel activator, can be used to treat hyperinsulinism.
3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-dioxide (Sch-6783) has a number of physiological effects, including lowering the blood pressure and rectifying hypoglycemia. Diazoxide has powerful protective properties against cardiac ischemia[1].
3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-dioxide (Sch-6783) could protect NSC-34 neurons against the main sources of neurodegenerative damage. Diazoxide increases Nrf2 nuclear translocation in NSC-34 motoneurons and prevents endogenous oxidative damage[2].
3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-dioxide (Sch-6783) attenuates postresuscitation brain injury, protects mitochondrial function, inhibits brain cell apoptosis, and activates the PKC pathway by opening mitoKATP channels[3]. Treatment with 3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-dioxide (Sch-6783) in wild-type mice decreases intraocular pressure (IOP) by 21.5±3.2% with an absolute IOP reduction of 3.9 ± 0.6 mm Hg[4].
Reference：
[1]. Coetzee WA, et al. Multiplicity of effectors of the cardioprotective agent, diazoxide. Pharmacol Ther. 2013 Nov;140(2):167-75.
[2]. Virgili N, et al. K(ATP) channel opener diazoxide prevents neurodegeneration: a new mechanism of action viaantioxidative pathway activation. PLoS One. 2013 Sep 11;8(9):e75189.
[3]. Wu H, et al. Diazoxide Attenuates Postresuscitation Brain Injury in a Rat Model of Asphyxial Cardiac Arrest by Opening Mitochondrial ATP-Sensitive Potassium Channels. Biomed Res Int. 2016;2016:1253842.
[4]. Chowdhury UR, et al. ATP-sensitive potassium (K(ATP)) channel openers diazoxide and nicorandil lower intraocular pressure in vivo. Invest Ophthalmol Vis Sci. 2013 Jul 22;54(7):4892-9.