Description: Blasticidin S 2HCl is a nucleoside antibiotic agent extracted from Stretomyces girseochromogenes, and acts as a DNA and protein synthesis inhibitor. It is used to select transfected cells carrying bsr or BSD resistance genes. In mouse leukemia L5178Y cells, blasticidin S inhibited protein synthesis and caused the degradation of presumptive mRNA [1]. Also, blasticidin S inhibited ribonuclease P activity from Dictyostelium discoideum and inhibited tRNA maturation in a dose dependent way.

References: J Biochem. 1966 Dec;60(6):632-42; Biochim Biophys Acta. 1977 Mar 2;475(1):14-22.

Related CAS: 2079-00-7 (free base); 3513-03-9 (HCl)

纯度：≥98%