BKM1740 is an inhibitor of survivin expression at both the mRNA and protein levels in vitro. BKM1740 induced apoptosis in prostate cancer (PCa) cells by repressing survivin. References: Seo SI, Gera L, Zhau HE, Qian WP, Iqbal S, Johnson NA, Zhang S, Zayzafoon M, Stewart J, Wang R, Chung LW, Wu D. BKM1740, an acyl-tyrosine bisphosphonate amide derivative, inhibits the bone metastatic growth of human prostate cancer cells by inducing apoptosis. Clin Cancer Res. 2008 Oct 1;14(19):6198-206. doi: 10.1158/1078-0432.CCR-08-1023. PubMed PMID: 18829499.

纯度：≥98%

CAS：1070966-97-0