Immunoproteasome inhibitor,potent and selective
CAS：960374-59-8
分子式：C31H40N4O7
分子量：580.67
纯度：98%
存储：Store at -20°C

Background:

ONX-0914, previously known as PR-975, is a potent inhibitor of immunoproteasome, a form of proteasome generating peptides presented on major histocompatibility complex (MHC) class I molecule to cytotixic T cells, which selectively induces conformational changes in the S1 binding pocket of the immunoproteasome subunit β5i (low molecular mass polypeptide 7/LMP7) rather than the constitutive proteasome subunit β5 in human and mouse cells. ONX-0914 is able to block the production of proinflammatory cytokines from human peripheral blood mononuclear cells (PBMCs), activate mouse splenocytes, inhibit IL-17-producing T cells under TH17-polarizing cytokinesinvitro, and attenuate disease progression of diabetes, arthritis, and colitis in mouse models.

Reference

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