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(3S)-hydroxy Quinidine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(3S)-hydroxy Quinidine图片
CAS NO:53467-23-5
规格:98%
分子量:340.4
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
(3S)-hydroxy Quinidine is an active quinidine metabolite.
CAS:53467-23-5
分子式:C20H24N2O3
分子量:340.4
纯度:98%
存储:Store at -20°C

Background:

(3S)-hydroxy Quinidine is an active quinidine metabolite. Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, CYP2E1, and CYP3A5, with CYP3A4 being the most active enzyme in the (3S)-hydroxy quinidine formation. (3S)-hydroxy Quinidine prolongs repolarization of canine Purkinje fibers in vitro and prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in isolated rat hearts in a dose-dependent manner.