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JSH-23 HCL
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JSH-23 HCL图片
CAS NO:749886-87-1
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
JSH-23 HCl is designed as an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM in RAW 264.7 cell line. JSH-23 inhibits NF-κB transcriptional activity in a dose-dependent manner in LPS-stimulated macrophages RAW 264.7. This effect is not due to its cytotoxicity. In the same condition, JSH-23 is found to significantly decrease the LPS-induced DNA binding activity of NF-κB while decrease nuclear amount of NF-κB p65. JSH-23 plays these roles without affecting IκB degradation. In addition, JSH-23 also shows inhibition effects on the expression of the pro-inflammatory transcripts and enzymes, including IL-6, IL-1β, COX-2 and TNF-α. Furthermore, JSH-23 inhibits LPS-induced apoptotic chromatin condensation.
理化性质和储存条件
Molecular Weight (MW)276.81
FormulaC16H21N2Cl
CAS No.545380-34-5
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO:>50 mg/mL
Water: N/A
Ethanol: N/A
Solubility (In vivo) 0.5% hydroxyethyl cellulose: 30 mg/mL
Chemical Name/Synonym4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine; JSH23; JSH 23; JSH-23
实验参考方法
In VitroEVP4593 inhibits TNF-a production from murine splenocytes stimulated with LPS with IC50 of 7 nM. EVP4593 (300 nM) entails a significant decrease of amplitude of store-operated currents (approximately by 60%), induced by application of 1 μM thapsigargin in Htt138Q cells, thus prevents abnormal store-operated calcium entry.
In VivoEVP4593 (1 mg/kg, i.p.) dose-dependently inhibits carrageenin-induced paw edema in rats.
Animal model male SD rats with carrageenin induced paw edema
Formulation & Dosage 0.5% hydroxypropyl cellulose; 1 mg/kg; i.p injection
References[1] Tobe M, et al. Bioorg Med Chem, 2003, 11(3), 383-391.