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ITF2357(Givinostat)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ITF2357(Givinostat)图片
CAS NO:732302-99-7
规格:98%
分子量:475.97
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
200mg电议
500mg电议
1g电议

产品介绍
HDAC inhibitor
CAS:732302-99-7
分子式:C24H27N3O4.HCl.H2O
分子量:475.97
纯度:98%
存储:Store at -20°C

Background:

ITF2357, also known as givinostat, is a potent inhibitor of both class I and class II histone deacetylase (HDAC) as well as a potent inhibitor of hematopoietic colony formation by JAKEV617F-bearing progenitor cells from chronic myeloproliferative neoplasmsin vitro. Previous studies has shown that ITF2357 induces apoptosis of multiple myeloma (MM) and acute myelogenous leukemia (AML) cells following induction of p21 and down-modulation of Bcl-2 and Mcl-1 proteins and inhibits the production of pro-inflammatory cytokines (such as IL-1, IL-6, tumor necrosis factor (TNF)-α and interferon (IFN)-γ) by peripheral blood mononuclear cells as well as the production of IL-6 and vascular endothelium growth factor (VEGF) by mesenchymal stromal cells.


Reference


?[1].Katia Todoerti, Valentina Barbui, Olga Pedrini, Marta Linett, Gianluca Fossati, Paolo Mascagni, Alessandro Rambaldi, Antonino Neri, Martino Introna, Luigia Lombardi, and Josee Golay. Pleiotropi anti-myeloma activity of ITF2357: inhibition of interleukin-6 receptor signaling and repression of miR-19a and miR-19b. Haematologica 2010; 95(2): 260-269