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Viridicatol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Viridicatol图片
CAS NO:14484-44-7
规格:98%
分子量:253.3
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Viridicatol is a fungal metabolite that has been found in various Penicillium species as well as Phoma.
CAS:14484-44-7
分子式:C15H11NO3
分子量:253.3
纯度:98%
存储:Store at -20°C

Background:

Viridicatol is a fungal metabolite that has been found in various Penicillium species as well as Phoma. It suppresses the expression of COX-2 and inducible nitric oxide synthase (iNOS) and inhibits production of nitric oxide and prostaglandin E2 (PGE2) in LPS-stimulated RAW 264.7 and BV2 cells. It also inhibits NF-κB DNA-binding activity, nuclear translocation of NF-κB p65 and p50 heterodimers, and blocks degradation of inhibitor of kappa B α (IκBα) in the cytoplasm of LPS-stimulated RAW 264.7 and BV2 cells. Viridicatol inhibits the growth of F. graminearum in a disc assay. It also inhibits protein tyrosine phosphatase 1B (PTB1B) in vitro (IC50 = 64 μM).