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Foropafant
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Foropafant图片
CAS NO:136468-36-5
规格:98%
分子量:464.72
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Foropafant (SR27417) 是一种高效、竞争性、选择性、可口服的血小板激活因子 (PAF) 受体拮抗剂,抑制 [3H]PAF 与其受体结合,Ki 值为 57 pM,比未被标记的 PAF 低至少 5 倍。Foropafant (SR27417) 有效抑制 PAF 诱导的兔和人血小板聚集。
CAS:136468-36-5
分子式:C28H40N4S
分子量:464.72
纯度:98%
存储:Store at -20°C

Background:

Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a Ki value of 57 pM for [3H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets[1]. Ki: 57 pM ([3H]PAF binding)[1]




[1]. Herbert JM, et al. Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist. J Pharmacol Exp Ther. 1991 Oct;259(1):44-51.