ROR agonist-1 是一种有效、口服可利用的视黄酸受体相关孤儿受体 C2 (RORC2) 反向激动剂，抑制人类原始 TH 17 细胞产生 IL-17A 的 pIC50 为7.5。
CAS：2361528-74-5
分子式：C21H20F6N2O5S
分子量：526.45
纯度：98%
存储：Store at -20°C

Background:

ROR agonist-1 is a potent and orally bioavailable inverse agonist of the retinoic acid receptor-related orphan receptor C2 (RORC2), inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5[1]. pIC 50: 7.5 (human primary TH 17 cells)[1]

[1]. von Berg S, et al. Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2. ACS Med Chem Lett. 2019 May 29;10(6):972-977.