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Thio-TEPA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Thio-TEPA图片
CAS NO:52-24-4
包装:1g
规格:98%
市场价:680元
分子量:189.22

产品介绍
alkylating agent used to treat cancer
CAS:52-24-4
分子式:C6H12N3PS
分子量:189.22
纯度:98%
存储:Store at -20°C

Background:

Thio-TEPA is a DNA alkylating agent, with antitumor activity.


Thio-TEPA exhibits alkylating activity in rat liver slice incubation. Thio-TEPA does not affect the viability of rat liver slices, and is not accumulated in the slices at all doses of 2, 5, 10 mM[1].


Thio-TEPA (20 mg/kg, i.p.) with total body irradiation (TBI) enhances donor-type blood chimerism during the first 10 weeks but is not dramatically higher than that of TBI group alone. Thio-TEPA alone improves both short- and long-term engraftment in mice[2].


参考文献:
[1]. Hagen B, et al. Metabolism and alkylating activity of thio-TEPA in rat liver slice incubation. Cancer Chemother Pharmacol. 1991;28(6):441-7.
[2]. Down JD, et al. Thiotepa improves allogeneic bone marrow engraftment without enhancing stem cell depletion in irradiated mice. Bone Marrow Transplant. 1998 Feb;21(4):327-30.