CAS NO: | 141206-42-0 |
规格: | 98% |
分子量: | 219.3 |
包装 | 价格(元) |
500ug | 电议 |
1mg | 电议 |
5mg | 电议 |
Background:
N-(n-Butyl)deoxygalactonojirimycin is an inhibitor of α-D-galactosidase. It has also been shown to prevent glucosylceramide biosynthesis both in vitro and in mouse models of lysosome storage disorders by inhibiting the ceramide-specific glucosyltransferase, UDP-glucose ceramide glucosyltransferase (IC50 = 41.4 µM) without affecting α-glucosidase I and II or β-glucocerebrosidase (IC50s >1 mM). This compound has been used to sensitize cultured chronic lymphocytic leukemia cells to the chemotherapeutic agents cladribine , chlorambucil , and fludarabine .