Neurotensin (8-13) 是神经降压素的活性片段，Neurotensin (8-13) 降低细胞表面NT1受体 (NTR1) 密度。
CAS：60482-95-3
分子式：C38H64N12O8
分子量：816.99
纯度：98%
存储：Store at -20°C

Background:

Neurotensin (8-13) is an active fragment of Neurotensin,. Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density. NTR1[1]

Receptor internalization induced by Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density. The receptor downregulation in response to high extracellular concentrations of the peptide has been described for Neurotensin (NT) in HT-29 cells and in rat primary cultured neurons. Reappearance of the receptors on the cell surface is also different[1].

[1]. GarcÍa-Garayoa E, et al. Preclinical evaluation of a new, stabilized neurotensin(8--13) pseudopeptide radiolabeled with (99m)tc. J Nucl Med. 2002 Mar;43(3):374-83.