CAY10621 is an inhibitor of sphingosine kinase 1 (SPHK1; IC50 = 3.3 μM).
CAS：120005-55-2
分子式：C26H45NO4
分子量：435.6
纯度：98%
存储：Store at -20°C

Background:

CAY10621 is an inhibitor of sphingosine kinase 1 (SPHK1; IC50 = 3.3 μM).[1]? It is selective for SPHK1 over SPHK2 at 10 μM and PKC at concentrations less than 100 μM. CAY10621 inhibits SPHK1 activity by 70% in U937 cells when used at a concentration of 5 μM.

Reference:
1. Wong, L., Tan, S.L., Lam, Y., et al. Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases. Journal of Medicinal Chemistry 52, 3618-3626 (2009).