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β-Amyloid(10-35),amide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:181427-66-7
规格:98%
分子量:2902.33
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
β-Amyloid(10-35),amide是一种含有26个氨基酸的多肽,由β-Amyloid肽的10-35残基组成。β-Amyloid(10-35)是阿尔兹海默症淀粉样斑块(Alzheimer'sdisease)的主要组成成分。
CAS:181427-66-7
分子式:C133H205N35O36S
分子量:2902.33
纯度:98%
存储:Store at -20°C

Background:

β-Amyloid (10-35), amide is composed of 26 aa (10-35 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease.


β-Amyloid (10-35) is selected based on the following considerations: (1) β-Amyloid (10-35) incorporates the core region, point mutations of which significantly obstruct fibril formation and have been used to generate inhibitors of fibrillogenesis; (2) β-Amyloid (10-35) retains the ability to add to bona fide Alzheimer’s plaques, in contrast to other truncated peptides, and forms fibrils morphologically similar to those of the full length peptide; (3) Of most importance, the full length peptide, Aβ(1-42), is intractable for the controlled formation of fibrils from aqueous media because at the earliest time points, some of the peptide exists as an amorphous precipitate. In contrast, the use of β-Amyloid (10-35) allows the reproducible and controlled formation of fibrils from aqueous solutions, under defined conditions of pH, ionic strength, and peptide concentration and thus yields the required homogeneous fibrils[1].



[1]. Benzinger TL, et al. Propagating structure of Alzheimer’s beta-amyloid(10-35) is parallel beta-sheet with residues in exact register. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13407-12.