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CID 16020046
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CID 16020046图片
CAS NO:834903-43-4
规格:98%
分子量:425.44
包装与价格:
包装价格(元)
100mg电议
200mg电议
10mg电议
50mg电议

产品介绍
CID 16020046是GPR55(LPI 受体) 选择性抑制剂, IC50为150nM。
CAS:834903-43-4
分子式:C25H19N3O4
分子量:425.44
纯度:98%
存储:Store at -20°C

Background:

CID 16020046 is a potent and selective GPR55(LPI receptor) antagonist; inhibitsGPR55 constitutive activity with IC50 of 0.15 uM.IC50 value: 0.15 uM [1]Target: GPR55 antagonistIn yeast cells expressing human GPR55, CID16020046 antagonized agonist-induced receptor activation. In human embryonic kidney(HEK293) cells stably expressing human GPR55, the compound behaved as an antagonist on LPI-mediated Ca2+ release and extracellular signal-regulated kinases activation, but not in HEK293 cells expressing cannabinoid receptor 1 or 2.CID16020046 concentration dependently inhibited LPI-induced activation of nuclear factor of activated T-cells (NFAT), nuclear factor k of activated B cells (NF-kB) and serum response element, translocation of NFAT and NF-kB, and GPR55 internalization. It reduced LPI-induced wound healing in primary human lung microvascular endothelial cells and reversed LPI-inhibited platelet aggregation.




[1]. Kargl J, et al. A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function. J Pharmacol Exp Ther. 2013 Jul;346(1):54-66.