Bisantrene HCl (CL216942 and NSC337766), the hydrochloride salt of Bisantrene, is potent inhibitor of topoisomerase II and DNA intercalators with anticancer activity. It may be used as model compounds to study P-glycoprotein-mediated multiple drug resistance (MDR1). Bisantrene may be used as a Rac1 inhibitor. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity.

纯度：≥98%

CAS：71439-68-4