LY334370 是一个选择性的 5-HT1F 受体激动剂，其 Ki 值为 1.6 nM。
CAS：182563-08-2
分子式：C21H22FN3O
分子量：351.42
纯度：98%
存储：Store at -20°C

Background:

LY334370 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM. Ki: 1.6 nM (5-HT1F)

LY334370 has no vasoconstrictor effects on human cerebral arteries in vitro until a dose of 10-5 M, at which it produces a contraction of 8.5±5.7%; however, this is not significant[1].

Following intravenous administration of LY334370 at 3 mg/kg (n=3) or 10 mg/kg (n=6) electrical stimulation evokes an increase in dural blood vessel diameter of 135±6% and 106±11%, respectively, which is not significantly different from the respective control values. LY334370 has no effect on dural blood vessel diameter per se, since the actualdural blood vessel diameter is 43±4 arbitrary units before drug and 43±4 arbitrary units 15 min after injection of LY334370 (10 mg/kg)[1].

[1]. Shepheard S, et al. Possible antimigraine mechanisms of action of the 5HT1F receptor agonist LY334370. Cephalalgia. 1999 Dec;19(10):851-8.