Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran.
CAS：1015167-40-4
分子式：C31H33N7O9
分子量：647.6
纯度：98%
存储：Store at -20°C

Background:

Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran . The prodrug of dabigatran, dabigatran etexilate , is hydrolyzed by plasma esterases to form dabigatran, which is metabolized primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT2B15 to form dabigatran acyl-β-D-glucuronide. Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma equipotently to dabigatran.