Bis(maltolato)oxovanadium(IV), also known BMOV is a Potent insulin mimetic. Bis(maltolato)oxovanadium(IV) normalizes glucose and lipid values and restores food and fluid intake to control levels in diabetic rats without increasing insulin levels (0.37 mmol/kg). It attenuates hyperinsulinemia and hypertension in spontaneously hypertensive rats. Its mechanism of action includes inhibition of PTP1B as well as other tyrosine phosphatases. The drug is nontoxic in vitro at useful concentrations and exhibits no signs of toxicity in mice at high orally bioavailable doses. References: Willsky GR, Goldfine AB, Kostyniak PJ, McNeill JH, Yang LQ, Khan HR, Crans DC. Effect of vanadium(IV) compounds in the treatment of diabetes: in vivo and in vitro studies with vanadyl sulfate and bis(maltolato)oxovandium(IV). J Inorg Biochem. 2001 May;85(1):33-42. PubMed PMID: 11377693.

纯度：≥98%

CAS：38213-69-3