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CPI-455
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CPI-455图片
CAS NO:1628208-23-0
规格:98%
分子量:314.77
包装与价格:
包装价格(元)
5mg电议
25mg电议
500mg电议
1g电议

产品介绍
KDM5 inhibitor
CAS:1628208-23-0
分子式:C16H15ClN4O
分子量:314.77
纯度:98%
存储:Store at -20°C

Background:

IC50: 10 nM


CPI-455 is a KDM5 inhibitor.


The KDM5 family of histone demethylases catalyzes the demethylation of histone H3 on lysine 4 (H3K4) and is required for the survival of drug-tolerant persister cancer cells (DTPs).


In vitro: Previous study found that CPI-455 could potently inhibit the fulllength KDM5A in enzymatic assays with a half-maximal inhibitory concentration of 10 ± 1 nM. CPI-455 inhibited KDM5A, KDM5B and KDM5C to similar levels but showed significantly weaker potency toward KDM4C and KDM7B (