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CB 300919
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CB 300919图片
CAS NO:289715-28-2
规格:98%
分子量:584.11
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Potential therapy for ovarian cancer
CAS:289715-28-2
分子式:C32H34ClN7O2
分子量:584.11
纯度:98%
存储:Store at -20°C

Background:

CB 300919 is a quinazoline-based antitumour agent with high activity in the CH1 human ovarian tumour xenograft. CB 300919 has a continuous exposure (96 h) growth inhibition IC50 value of 2 nM in human CH1 ovarian tumor xenograft[1].


参考文献:
[1]. Lockman JW, et al. Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as Potent Inhibitors of Nicotinamide Phosphoribosyltransferase (Nampt). J. Med. Chem., 2010, 53 (24), pp 8734-8746
[2]. Bavetsias, V. et al. The Design and Synthesis of Water-Soluble Analogues of CB30865, a Quinazolin-4-one-Based Antitumor Agent. Journal of Medicinal Chemistry (2002), 45(17), 3692-3702.