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Salubrinal
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Salubrinal图片
CAS NO:405060-95-9
规格:98%
分子量:479.81
包装与价格:
包装价格(元)
10mg电议
25mg电议

产品介绍
Selective eIF2α inhibitor
CAS:405060-95-9
分子式:C21H17Cl3N4OS
分子量:479.81
纯度:98%
存储:Store at -20°C

Background:

IC50: A cell-permeable and selective inhibitor of eIF2α dephosphorylation with an IC50 of 15 M.


The eukaryotic translation initiation factor 2 subunit α (eIF2α) is crucial in protein synthesis. eIF2α phosphorylation played an important role in protecting cells from apoptosis. Salubrinal selectively suppresses the phosphatase complexes that dephosphorylate eIF-2α. [1]


In vitro: This agent is reported to protect cells from endoplasmic reticulum (ER) stress-induced apoptosis (EC50