CAS NO: | 405060-95-9 |
规格: | 98% |
分子量: | 479.81 |
包装 | 价格(元) |
10mg | 电议 |
25mg | 电议 |
Background:
IC50: A cell-permeable and selective inhibitor of eIF2α dephosphorylation with an IC50 of 15 M.
The eukaryotic translation initiation factor 2 subunit α (eIF2α) is crucial in protein synthesis. eIF2α phosphorylation played an important role in protecting cells from apoptosis. Salubrinal selectively suppresses the phosphatase complexes that dephosphorylate eIF-2α. [1]
In vitro: This agent is reported to protect cells from endoplasmic reticulum (ER) stress-induced apoptosis (EC50