CB-7921220 is an inhibitor of the adenylyl cyclase (AC) isoforms AC1 and AC6.
CAS：115453-99-1
分子式：C14H12N2O2
分子量：240.3
纯度：98%
存储：Store at -20°C

Background:

CB-7921220 is an adenylate cyclase inhibitor.

CB-7921220 shows a degree of isoform selectivity for adenylate cyclase (AC) 1, but cannot distinguish between AC1 and AC6. CB-7921220 has a more consistent predicted binding position in the two virtual docking screens, and has a binding conformation similar to ATP and P-site inhibitors, which may explain its lack of selectivity between AC1 and AC6[1].

参考文献:
[1]. Brand CS, et al. Isoform selectivity of adenylyl cyclase inhibitors: characterization of known and novel compounds. J Pharmacol Exp Ther. 2013 Nov;347(2):265-75.