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Hirsutine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hirsutine图片
CAS NO:7729-23-9
规格:98%
分子量:368.47
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Hirsutine,一种 Uncaria rhynchophylla 的吲哚生物碱,具有抗癌活性。Hirsutine 诱导细胞凋亡,并且是一种有效的 Dengue virus 抑制剂,具有低毒性。
CAS:7729-23-9
分子式:C22H28N2O3
分子量:368.47
纯度:98%
存储:Store at -20°C

Background:

Hirsutine, an indole alkaloid of Uncaria rhynchophylla, exhibits anti-cancer activity. Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity[1][2][3].


Hirsutine remarkably reduces the viability of MCF-7 and MDA-MB-231 cells in a time- and dose-dependent manner with IC50 values of 447.79 and 179.06 μM, respectively. In the MDA-MB-231 cells, Hirsutine induces apoptosis and depolarization of MMP, releases Cyt C from mitochondria, and activates caspase 9 and caspase 3[2].


Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells[3].


[1]. Hishiki T, et al. Hirsutine, an Indole Alkaloid of Uncaria rhynchophylla, Inhibits Late Step in Dengue Virus Lifecycle. Front Microbiol. 2017 Aug 30;8:1674. [2]. Huang QW, et al. [Hirsutine induces apoptosis of human breast cancer MDA-MB-231 cells through mitochondrial pathway]. Sheng Li Xue Bao. 2018 Feb 25;70(1):40-46. [3]. Zhang R, et al. Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells. Cell Death Dis. 2018 May 22;9(6):598.