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Ac-YVAD-AFC
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ac-YVAD-AFC图片
CAS NO:219137-85-6
规格:98%
分子量:719.66
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Fluorogenic peptide substrate for caspase-1
CAS:219137-85-6
分子式:C33H36F3N5O10
分子量:719.66
纯度:98%
存储:Store at -20°C

Background:

Ac-YVAD-AFC is a substrate whose amino acids YVAD have been shown to be a preferred cleavage site for caspase-1 and -4.[1],[2] Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.


Reference:
[1]. Talanian, R.V., Quinlan, C., Trautz, S., et al. Substrate specificities of caspase family proteases. J. Biol. Chem. 272(15), 9677-9682 (1997).
[2]. Marcelli, M., Cunningham, G.R., Haidacher, S.J., et al. Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP. Cancer Res. 58(1), 76-83 (1998).