Acetyldigitoxin is cardiac glycoside and an inhibitor of the Na+/K+ ATPase with an IC50 value of 5 nM in isolated rat pinealocytes.
CAS：1111-39-3
分子式：C43H66O14
分子量：807
纯度：98%
存储：Store at -20°C

Background:

Acetyldigitoxin is cardiac glycoside and an inhibitor of the Na+/K+ ATPase with an IC50 value of 5 nM in isolated rat pinealocytes. This inhibition results in loss of the transmembrane Na+ gradient, which decreases activity of the Na+/Ca2+ exchanger, increasing intracellular calcium levels, inotropy, and cardiac force. Formulations containing acetyldigitoxin have been used for the treatment of heart failure and chronic atrial fibrillation.