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Coenzyme A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Coenzyme A图片
CAS NO:85-61-0
规格:98%
分子量:767.5
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍

Coenzyme A (CoA) is an essential cofactor functioning as an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism.
CAS:85-61-0
分子式:C21H36N7O16P3S
分子量:767.5
纯度:98%
存储:Store at -20°C

Background:

Coenzyme A is is an obligatory cofactor in all living cells synthesised from pantothenate (Vitamin B5), adenosine triphosphate (ATP) and cysteine. Covalent binding of Coenzyme A to Peroxiredoxin 5 (Prdx5) results in complete inhibition of its peroxidase activity, which is reversed by reduction with DTT.Coenzyme A and its thioester derivatives are key players in major catabolic and anabolic pathways and the regulation of gene expression. Many human pathologies, including cancer, diabetes and neurodegeneration, have been associated with abnormal biosynthesis and homeostasis of CoA and its derivatives[1].

参考文献:
[1]. Bakovi? J, et al. A key metabolic integrator, coenzyme A, modulates the activity of peroxiredoxin 5 via covalent modification. Mol Cell Biochem. 2019 Aug 2.