LP-44 is a high affinity 5-HT7 receptor agonist (Ki = 0.22 nM) that exhibits selectivity over 5-HT1A and 5-HT2A receptors (200- and > 1000-fold respectively). LP-44 dnduces relaxation of substance P-stimulated guinea pig ileum (EC50 = 2.56 μM). References: Demirkaya K, Akgün OM, Senel B, Oncel Torun Z, Seyrek M, Lacivita E, Leopoldo M, Dogrul A. Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in mice. J Appl Oral Sci. 2016 May-Jun;24(3):218-22. doi: 10.1590/1678-775720150563. PubMed PMID: 27383702; PubMed Central PMCID: PMC5022221.

纯度：≥98%

CAS：824958-12-5